Updates on Management of Chronic Renal Disease
Chronic kidney disease (CKD) is the most common kidney disease in cats, estimated to affect 0.5-1.5% of the general population and 30% of cats over 15 years. The term CKD or chronic renal disease is non-specific, but preferred to "chronic renal failure" or "chronic renal insufficiency" as owners understand the terminology and the negative context imbued by "failure" is avoided.
Guidelines for staging cats with CKDwereestablished by the International Renal Interest Society (IRIS)(http://www.IRISkidney.com) and providea useful classification system for ongoing monitoring and information on expected outcome.CKD stagingis based on serum/plasma creatinine concentration and recently, symmetric dimethylarginine (SDMA) has also been included in the guidelines. It is important to note that the specificity of SDMA has not been tested in large scale prospective studies. A recent study compared SDMA, creatinine and glomerular filtration rate in 49 cats that were normal or had CKD or diabetes mellitus (Brans et al JVIM2020). SDMA was a reliable marker of reduced GFR but superiority of SDMA over creatinine could be demonstrated...
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