Step-by-Step Guide to Darbepoetin Injections

Darbepoetin injections help cats with chronic kidney disease (CKD) manage anemia, a condition in which they cannot produce enough red blood cells. This guide explains the process and what to expect.

What is Darbepoetin, and why is it needed?

Kidney function and red Blood cells:
In healthy cats, the kidneys produce a hormone called erythropoietin. This hormone signals the bone marrow to produce new red blood cells.

CKD and snemia:
As a cat’s kidneys start to fail, they stop producing erythropoietin. This leads to non-regenerative anemia, where the body can’t replace old red blood cells. Over time, this can cause cats to become lethargic and lose energy, especially in the later stages of CKD.

Darbepoetin:
Darbepoetin is a human-made version of erythropoietin that helps the body produce new red blood cells, improving the cat’s energy levels and overall quality of life.

How the treatment works:
Initial treatment:
Most cats start with weekly darbepoietin injections.

Monitoring:
Before each injection, the cat is tested for overall health, including weight and blood pressure. A packed cell volume (PCV) test is also performed to assess the severity of the anemia and determine the effectiveness of the treatment

Response to treatment:
Approximately 60% of cats respond to darbepoietin by showing an increase in red blood cell counts. If the PCV reaches a normal range, the frequency of injections may be reduced (e.g., every two to three weeks).

Potential side effects

High blood pressure:
This is the most common side effect in about 50% of cats. Blood pressure is checked before each treatment to monitor for this.

Seizures:
It is a less common side effect but still possible.

Pure red cell aplasia:
About 10% of cats develop antibodies against darbepoetin or their own red blood cells, causing pure red cell aplasia. If this occurs, treatment must be stopped.

Treatment benefits

Most cats that respond to darbepoetin see significant improvements in energy levels and overall quality of life.

While potential side effects exist, they tend to be mild, and the benefits often outweigh the risks.

Are you worried about your cat’s health?

If you are concerned about your cat, please reach out to our friendly team. Call us on 1300 228 377 or fill out the contact form below. In an emergency, please contact your local vet.

For vets – to refer a patient or book a telehealth consultation, please call us on 1300 228 377, book through the portal or fill in the form.

Patient Stories

Our commitment to feline health is best seen in the stories of the cats we’ve had the privilege of treating. These journeys highlight the dedication, expertise and compassion that drive us.

Each patient faced unique challenges, and it was our honour to offer high-quality care and help them regain strength and happiness. We value the deep bonds with cats and their owners, knowing the difference we make in their lives.

See All Stories

The road to recovery for Kuro

Kuro is a calm and dignified older cat who faced a challenging case of hyperthyroidism and early kidney changes.

Kikki’s transformation after I-131

Kikki is a gentle and resilient cat who came to CSS with a long-standing case of hyperthyroidism and significant heart changes.

Bubba beats hyperthyroidism

Bubba is a charming ginger and white cat who came to us after his owner noticed he was hunting more, eating voraciously and losing weight, all subtle signs of hyperthyroidism.

Expert care and a tailored plan saved Ed from pancreatitis

Pancreatitis is an inflammatory condition that disrupts digestion and often goes unnoticed until a cat becomes seriously ill. That was the case for Ed, whose vague symptoms progressed into a life-threatening emergency. Thankfully, with expert care from Cat Specialist Services, she made a full recovery.

Tango Triumphs Over FIP

At 5 months old, Tango was diagnosed with Feline Infectious Peritonitis (FIP). Once considered a fatal disease, the introduction of new treatments has significantly boosted the survival rate.

Contacting Us

Pet Owners
If you would like to talk about treatment for your cat, call us on 1300 228 377 or fill in the form.
In an emergency, please contact your local vet.

Vets and Nurses
To refer a patient or book a telehealth consultation please call us on 1300 228 377, book through the portal or fill in the form. For advice calls, please see the guidelines here.

1300 228 377

1-15 Lexington Rd,
Underwood, QLD, AU, 4119

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Saturday/Sunday - Closed